Coronary haemodynamic effects of nifedipine. Comparison with glyceryl trinitrate.

Comparison with glyceryl trinitrate

The coronary haemodynamic effects of nifedipine and glyceryl trinitrate were compared in 22 patients undergoing investigations for suspected coronary artery disease. Myocardial blood flow was estimated by the coronary sinus thermodilution technique. In sinus rhythm nifedipine increased mean coronary sinus flow from 135 ml/min to 152 m/min, and reduced arterio-coronary sinus oxygen difference fr...

Comparison of haemodynamic effects of phentolamine, sodium nitroprusside, and glyceryl trinitrate in acute myocardial infarction.

The effects of the commonly employed systemic vasodilators phentolamine, nitroprusside, and intravenous glyceryl trinitrate on cardiac performance, peripheral resistance, and vascular capacitance, as judged by changes in left ventricular filling pressure, were compared in 29 patients studied within 24 hours after the onset of acute myocardial infarction. To provide a common basis for comparison...

Glyceryl trinitrate before coronary angiography.

Haemodynamic effects of glyceryl trinitrate during continuous 24 hour infusion in patients with heart failure.

OBJECTIVE To investigate whether the susceptibility to tolerance to glyceryl trinitrate is similar in different vascular beds in patients with chronic heart failure. PATIENTS Twenty patients with heart failure underwent a continuous infusion of glyceryl trinitrate over 24 hours followed by administration of N-acetylcysteine (5 g intravenously) in a bolus. MAIN OUTCOME MEASURES Haemodynamic ...

Haemodynamic effects of hydrallazine and of hydrallazine plus glyceryl trinitrate paste in heart failure.

In a study designed to investigate potential non-parenteral treatment for chronic heart failure, hydrallazine, 225 to 300 mg per day, was given orally to 9 patients. There was no significant change in heart rate or mean arterial pressure as cardiac output increased. Left ventricular stroke work increased significantly and pulmonary artery wedge pressure fell. Systemic and pulmonary vascular res...